Materials From April to April , 68 critical patients with severe organophosphorus poisoning treated in our hospital were enrolled into this study. Support Center Support Center. Prognostic value of serum cholinesterase in organophosphate poisoning. Acute organophosphorus pesticide poisoning can cause consciousness disorders. Lee P, Tai DY. Plasma cholinesterase activity is a biomarker sensitive to the effect of organophosphate and carbamate pesticides.

Types of poisoning include the following: A systematic review and meta-analysis. Thirty-four patients received hemodialysis and hemoperfusion for times, and 25 patients had complications. Rajapakse VP, Wijesekera S. In this model, rats are typically pretreated with pyridostigmine bromide PB , a reversible cholinesterase inhibitor, to enhance survival The conditions of patients with severe organophosphorus poisoning are unstable with a high fatality rate, and immediate rescue and appropriate therapy are very vital for them.

This suggests that different OP have different toxicities. Differences between organophosphorus insecticides in human self-poisoning. Targeting the htesis system to counteract organophosphate poisoning: Table 3 Comparison of rescue outcomes.

thesis on organophosphorus poisoning

One of the devastating effects of acute exposure to organophosphates, like nerve agents, is the induction of oganophosphorus and prolonged status epilepticus SEwhich can cause death, or brain damage if death is prevented. The instruments used include a disposable HA hemoperfusion apparatus and single-pump hemodialysis machine Japan.

If patients are combined with acute renal failure, pulmonary edema, heart failure, and cephaledema, its effects are unsatisfactory. This retrospective study examined the comprehensive medical, nursing, and intensive care records of 68 patients admitted to the Institute of Pesticide Poisoning at Soonchunhyang University Cheonan Hospital, Cheonan, Korea, for acute OP poisoning between January and December Table 5 Comparison of prognostic thezis.


Acute poisoning is a public health threat that leads to morbidity and ooisoning worldwide. This article has been cited by other articles in PMC. Chin Crit Care Med ; 4: Chlorpyrifos CPFan OP compound highly used, promotes, similarly to other OP, inhibition of the cholinesterases ChEs leading to the accumulation of acetylcholine in the central and peripheral cholinergic synapses.

Total cholinesterase activities were determined by radiometric assay.

organophosphate poisoning

The differences between these 2 groups were statistically significant. Patients in the control group received routine emergency treatment, while patients in the treatment group additionally received hemoperfusion plus hemodialysis on the basis of routine emergency treatment. The early, adequate and proper use of anticholinergic drugs is an important influence factor for the success of rescue.

These enzymatic levels are unknown for most of the wild birds analyzed in this study. Journal List Medicine Baltimore v. Acute cholinergic manifestations predominate with many patients requiring intensive care management and ventilator support. Observation and treatment of acute complications during the hemodialysis. Human butyrylcholinesterase BChE is a well-characterized bioscavenger with significant potential as a prophylactic or post-exposure treatment for organophosphate poisoning.

In a study of 52 OP-poisoned patients, Altinop et al. Author information Article notes Copyright and License information Disclaimer.


thesis on organophosphorus poisoning

Types of poisoning include Dipterex poisoning in 14 patients, methyl parathion poisoning in 10 patients, methamidophos poisoning in 5 patients, and dichlorvos poisoning in 5 patients. J Toxicol Clin Orbanophosphorus.

Factors for Determining Survival in Acute Organophosphate Poisoning

Organophosphates account for many of the world’s deadliest poisons. Prophylactic potential of memantine against soman poisoning in rats.

thesis on organophosphorus poisoning

In this study, we aimed to establish a baseline level of normal brain AChE activity in wild birds. The World Health Organization WHO estimates that the incidence of pesticide poisoning in developing countries has doubled during the past 10 years [ 5 ]. Hemodialysis technique can fully eliminate poisons with small molecular weight, low lipid solubility, and bonding rate with proteins organophoxphorus on diffusion and ultrafiltration effects.

The curative effects in these 2 groups and the prognosis after rescue were compared. An age over 60 years was also a significantly predictor of a poor outcome OR, 6. The management protocol for each OP in humans needs further study. Therefore, it is unable to correct water and electrolyte disturbance and acid—base imbalance.